Factors Associated With in-Hospital Mortality in a Geriatric Acute Care Unit in Yaoundé, Cameroon: A Cross-Sectional Study
Facteurs Associés à la Mortalité Hospitalière en Court Séjour Gériatrique à Yaoundé (Cameroun) : Une Étude Transversale Analytique
DOI:
https://doi.org/10.5281/zenodo.18527295Keywords:
Acute Geriatric Care, Geriatric Epidemiology, Mortality, CameroonAbstract
RÉSUMÉ
Introduction. Dans les services de court séjour gériatrique, la mortalité hospitalière constitue un indicateur majeur de la qualité des soins et de la vulnérabilité des patients âgés hospitalisés. La présente étude visait à identifier les facteurs associés à la mortalité en court séjour gériatrique à l’Hôpital Central de Yaoundé. Méthodes. Nous avons mené une étude transversale analytique avec collecte rétrospective des données dans le service de gériatrie de l’Hôpital Central de Yaoundé. Nous avons inclus les dossiers des patients âgés de 65 ans et plus hospitalisés entre le 1er janvier 2022 et 31 décembre 2024. Les données sociodémographiques, cliniques, biologiques ainsi que le devenir hospitalier ont été collectées. Une analyse multivariée par régression logistique a été effectuée afin d’identifier les facteurs associés à la mortalité avec un seul de significativité P < 0,05. Résultats. Nous avons inclus 205 patients dont une majorité de femmes (59,5%) et un âge médian de 80 (74-85) ans. La plupart des patients vivaient en milieu urbain (86,9%) et en famille (98,1%). Les comorbidités étaient dominées par l’hypertension artérielle (57,6%), le diabète de type 2 (23,4%) et l’arthrose (23,4%). La perte d’indépendance fonctionnelle (59%), la dénutrition (49,5%) et la confusion mentale (40%) étaient les principaux syndromes gériatriques. Le taux mortalité était de 17%. En analyse univariée, les facteurs associés à la mortalité étaient : la dénutrition, la confusion mentale, les escarres, la présence d’un sepsis, d’un cancer, d’une pneumonie d’inhalation, d’une anémie, d’une hyperleucocytose, d’un syndrome inflammatoire et d’une hypernatrémie. La présence d’un sepsis était le seul facteur associé à la mortalité en analyse multivariée. Conclusion. La présence d’un sepsis était indépendamment associée à la mortalité au sein de ce groupe de patients admis en court séjour gériatrique au Cameroun. La prise en charge précoce des infections chez la personne âgée pourrait réduire la mortalité.
ABSTRACT
Introduction. In acute geriatric care units, in-hospital mortality is a key indicator of both quality of care and the vulnerability of hospitalized older adults. This study aimed to identify factors associated with mortality in the acute geriatric unit of the Yaoundé Central Hospital. Methods: We conducted a cross-sectional study with retrospective data collection in the geriatric unit of the Yaoundé Central Hospital. We included medical records of patients aged ≥ 65 years hospitalized between January 1, 2022 and December 31, 2024. Sociodemographic, clinical, and biological data as well as in-hospital outcomes were collected. A multivariable logistic regression analysis was performed to identify factors associated with mortality, with a significance threshold of P < 0.05. Results. A total of 205 patients were included, the majority of whom were women (59.5%), with a median age of 80 (74–85) years. Most patients lived in urban areas (86.9%) and with family (98.1%). The main comorbidities were hypertension (57.6%), type 2 diabetes (23.4%), and osteoarthritis (23.4%). Activities of daily living (ADLs) dependency (59%), malnutrition (49.5%), and delirium (40%) were the most common geriatric syndromes. The mortality rate was 17%. In univariate analysis, factors associated with mortality included malnutrition, delirium, pressure ulcers, sepsis, cancer, aspiration pneumonia, anemia, leukocytosis, inflammatory syndrome, and hypernatremia. In multivariate analysis, sepsis was the only factor independently associated with mortality. Conclusion. Sepsis was independently associated with mortality in this group of patients admitted to the acute geriatric unit in Cameroon. Early identification and management of infections in older adults may help reduce mortality.
References
1. McLigeyo SO. Ageing population in Africa and other developing communities: a public health challenge calling for urgent solutions. East Afr Med J [Internet]. 2002 [cited 2023 Jul 27];79:281–3. Available from: https://pubmed.ncbi.nlm.nih.gov/12638817/
2. Shetty P. Grey matter: Ageing in developing countries. Lancet [Internet]. 2012 [cited 2023 Jul 27];379:1285–7. Available from: http://www.thelancet.com/article/S0140673612605418/fulltext
3. Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel J-P, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet [Internet]. 2016;387:2145–54. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0140673615005164
4. Covinsky KE, King JT, Quinn LM, Siddique R, Palmer R, Kresevic DM, et al. Do Acute Care for Elders Units Increase Hospital Costs? A Cost Analysis Using the Hospital Perspective. J Am Geriatr Soc [Internet]. 1997;45:729–34. Available from: https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.1997.tb01478.x
5. Ponzetto M, Maero B, Maina P, Rosato R, Ciccone G, Merletti F, et al. Risk Factors for Early and Late Mortality in Hospitalized Older Patients: The Continuing Importance of Functional Status. Journals Gerontol Ser A [Internet]. 2003 [cited 2023 Feb 5];58:M1049–54. Available from: https://academic.oup.com/biomedgerontology/article/58/11/M1049/640353
6. Tumaini B, Munseri P, Pallangyo K. Disease spectrum and outcomes among elderly patients in two tertiary hospitals in Dar es Salaam, Tanzania. PLoS One [Internet]. 2019 [cited 2023 Feb 5];14:e0213131. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213131
7. Goh KS, Low SKM, Zhang D, Png GK, Lin H, Ang WST, et al. Mortality predictors in an acute care geriatric unit in Singapore. Proc Singapore Healthc [Internet]. 2018;27:265–9. Available from: http://journals.sagepub.com/doi/10.1177/2010105818762915
8. Palmer RM, Landefeld CS, Kresevic D, Kowal J. A Medical Unit for the Acute Care of the Elderly. J Am Geriatr Soc [Internet]. 1994 [cited 2023 Feb 5];42:545–52. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1532-5415.1994.tb04978.x
9. Palmer RM. The Acute Care for Elders Unit Model of Care. Geriatr 2018, Vol 3, Page 59 [Internet]. 2018 [cited 2023 Feb 5];3:59. Available from: https://www.mdpi.com/2308-3417/3/3/59/htm
10. Liu P, Hao Q, Hai S, Wang H, Cao L, Dong B. Sarcopenia as a predictor of all-cause mortality among community-dwelling older people: A systematic review and meta-analysis. Maturitas [Internet]. 2017;103:16–22. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378512216304029
11. Hao Q, Zhou L, Dong B, Yang M, Dong B, Weil Y. The role of frailty in predicting mortality and readmission in older adults in acute care wards: a prospective study. Sci Rep [Internet]. 2019;9:1207. Available from: https://www.nature.com/articles/s41598-018-38072-7
12. Massamba Ba, Assane Sall, Rokhaya Djajhete, Dalahata Ba MC. Study of the Prevalence and Factors Associated with the Deaths of Elderly People Hospitalised at the Fann Geriatric Unit Dakar (Senegal). Acta Sci Med Sci. 2023;7:83–94.
13. K A Wade, A Diaby, E M Niang, A Diallo BD. Outcome of elderly patients in an intensive care unit in Dakar, Senegal. Med Sante Trop. 2012;22:223–4.
14. Sanya EO, Abiodun AA, Kolo PO, Olanrewaju T, Adekeye K. Profile and causes of mortality among elderly patients seen in a tertiary care hospital in Nigeria. Ann Afr Med [Internet]. 2011 [cited 2023 Feb 5];10:278. Available from: https://www.annalsafrmed.org/article.asp?issn=1596-3519;year=2011;volume=10;issue=4;spage=278;epage=283;aulast=Sanya
15. Adebusoye LA, Cadmus EO, Owolabi MO, Ogunniyi A. Frailty and mortality among older patients in a tertiary hospital in Nigeria. Ghana Med J [Internet]. 2019 [cited 2023 Feb 5];53:210–6. Available from: https://www.ajol.info/index.php/gmj/article/view/190012
16. Institut National de la Statistique. Enquête Démographique et de Santé 2018. Ministère de La Santé Publique, editor. 2020.
17. Marie-Josiane Ntsama Essomba RMMM, Ottou MZ, Madeleine, Singwe N. In-Hospital Mortality and Associated Factors in Acute Geriatric Care in Cameroon : A Retrospective Study. 2023;24:15–8.
18. Katz S. Assessing Self-maintenance: Activities of Daily Living, Mobility, and Instrumental Activities of Daily Living. J Am Geriatr Soc [Internet]. 1983 [cited 2023 Feb 5];31:721–7. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1532-5415.1983.tb03391.x
19. Kaiser MJ, Bauer JM, Ramsch C, Uter W, Guigoz Y, Cederholm T, et al. Validation of the Mini Nutritional Assessment short-form (MNA®-SF): A practical tool for identification of nutritional status. J Nutr Heal aging [Internet]. 2009;13:782–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1279770723020018
20. Pereira M, Rodrigues N, Godinho I, Gameiro J, Neves M, Gouveia J, et al. Acute kidney injury in patients with severe sepsis or septic shock: a comparison between the ‘Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease’ (RIFLE), Acute Kidney Injury Network (AKIN) and Kidney Disease: Improving Global Outcom. Clin Kidney J [Internet]. 2016;sfw107. Available from: https://academic.oup.com/ckj/article-lookup/doi/10.1093/ckj/sfw107
21. Adebusoye LA, Kalula SZ. Mortality among older patients admitted to the medical wards of Groote Schuur Hospital, Cape Town, South Africa, 2010 - 2013. South African Med J [Internet]. 2019;109:116. Available from: http://www.samj.org.za/index.php/samj/article/view/12532
22. Bâ M, Sall A, Djajheté R, Diallo I, Bâ D, Coumé M. Profiles of Major Cognitive Disorders in Elderly People Followed at the Geriatric Clinic of Fann National University Hospital in Senegal. J Biosci Med [Internet]. 2023;11:161–72. Available from: https://www.scirp.org/journal/doi.aspx?doi=10.4236/jbm.2023.1112015
23. Ministère de la Santé Publique. Stratégie Nationale de Développement 2020-2030 Pour la transformation structurelle et le développement inclusif, SND30 [Internet]. Available from: http://cdnss.minsante.cm/?q=fr/content/stratégie-nationale-de-développement-2020-2030-pour-la-transformation-structurelle-et-le
24. Presta R, Brunetti E, Salone B, Schiara LAM, Villosio C, Staiani M, et al. Short-term mortality and associated factors among older hospitalized patients: A narrative retrospective analysis of end-of-life care in an acute geriatric unit. Geriatr Nurs (Minneap) [Internet]. 2024;60:225–30. Available from: https://linkinghub.elsevier.com/retrieve/pii/S019745722400288X
25. Moen K, Ormstad H, Wang-Hansen MS, Brovold T. Physical function of elderly patients with multimorbidity upon acute hospital admission versus 3 weeks post-discharge. Disabil Rehabil [Internet]. 2018;40:1280–7. Available from: https://www.tandfonline.com/doi/full/10.1080/09638288.2017.1294211
26. Muneera K, Muhammad T, Pai M, Ahmed W, Althaf S. Associations between intrinsic capacity, functional difficulty, and fall outcomes among older adults in India. Sci Rep [Internet]. 2023;13:9829. Available from: https://www.nature.com/articles/s41598-023-37097-x
27. Adebusoye LA, Olowookere OO, Ajayi SA, Akinmoladun VI, Alonge TO. Mortality Trends among Older Patients Admitted to the Geriatric Centre, University College Hospital, Ibadan, Nigeria, 2013-2017. West Afr J Med [Internet]. 2020;37:209–15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/32476112
28. Adebusoye L, Owolabi M, Kalula S, Ogunniyi A. All-cause mortality among elderly patients admitted to the medical wards of hospitals in Africa: A systematic review. Niger J Heal Sci [Internet]. 2015 [cited 2023 Feb 5];15:45. Available from: http://www.https//chs-journal.com/article.asp?issn=1596-4078;year=2015;volume=15;issue=1;spage=45;epage=51;aulast=Adebusoye
29. Frasca D, Blomberg BB. Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology [Internet]. 2016;17:7–19. Available from: http://link.springer.com/10.1007/s10522-015-9578-8
30. Burke LA, Rosenfeld AG, Daya MR, Vuckovic KM, Zegre-Hemsey JK, Felix Diaz M, et al. Impact of comorbidities by age on symptom presentation for suspected acute coronary syndromes in the emergency department. Eur J Cardiovasc Nurs [Internet]. 2017;16:511–21. Available from: https://academic.oup.com/eurjcn/article/16/6/511-521/5925624
31. Ginoux M, Turquier S, Chebib N, Glerant J-C, Traclet J, Philit F, et al. Impact of comorbidities and delay in diagnosis in elderly patients with pulmonary hypertension. ERJ Open Res [Internet]. 2018;4:00100–2018. Available from: https://publications.ersnet.org/lookup/doi/10.1183/23120541.00100-2018
32. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med [Internet]. 2021;47:1181–247. Available from: https://link.springer.com/10.1007/s00134-021-06506-y
33. Tapsiz H, Yolcu S, Yilmaz N, Tunc M, Kaya A, Avci A. Comparison of national early warning score-2 and qSOFA in predicting the prognosis of older adults with altered mental status. Irish J Med Sci (1971 -) [Internet]. 2023;192:1355–9. Available from: https://link.springer.com/10.1007/s11845-022-03102-x
34. Casallas-Barrera JO, Zabala-Muñoz DA, Aponte-Carrascal CV, Ochoa-Ricardo AM, Quintero-Varela EF, Quiñones-Romero JN, et al. Prediction of mortality in cardio-neurovascular patients with sepsis and septic shock: is NEWS-2 better than qSOFA, SOFA, and qPitt? An observational study. Ther Adv Infect Dis [Internet]. 2025;12. Available from: https://journals.sagepub.com/doi/10.1177/20499361251323207
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Copyright (c) 2026 Marie-Josiane Ntsama Essomba, Mikal Ange Makoumpo Sa’ah, Maurice Avodo Avodo2, Atoumane Faye, Régine Mylène Mballa M, Mamadou Coume, Madeleine Ngandeu

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