Orbital Metastasis of Lobular Breast Carcinoma: A Case Report
Métastase Orbitaire d’un Carcinome Lobulaire du Sein : A Propos d’un Cas
DOI:
https://doi.org/10.5281/hra.v3i5.6707Keywords:
orbital metastasis, breast cancer, Burkina FasoAbstract
RÉSUMÉ
Les métastases de l’orbite sont rares. Elles peuvent être révélatrices d’un cancer ou survenir au cours de l’évolution d’un cancer déjà connu. Des symptômes tels que la rougeur, la douleur, l’exophtalmie peuvent être des manifestations d’une métastase orbitaire. Nous rapportons le cas d’une patiente de 49ans qui a présenté une lésion tumorale orbitaire révélée par un œdème péri orbitaire associée à des troubles visuels et une exophtalmie dont la nature métastatique a été confirmée par une étude histologique et immunohistochimique. Le traitement a consisté en une irradiation locale associée à des traitements systémiques. Les métastases orbitaires doivent être reconnues et traitées afin de préserver le pronostic visuel et la qualité de vie des patients.
ABSTRACT
Orbital metastases are rare and can either indicate the presence of an underlying cancer or occur during the progression of a pre-existing cancer. Redness, pain, and exophthalmos may be signs of orbital metastasis. We present the case of a 49-year-old woman who developed an orbital tumor, initially identified by peri-orbital edema, along with visual disturbances and exophthalmos. The metastatic nature of the lesion was confirmed through histological and immunohistochemical examination. Treatment involved local radiation therapy combined with systemic therapy. Orbital metastases should be promptly recognized and managed to preserve visual function and the patient's quality of life.
References
1.Bonavolontà G, Strianese D, Grassi P et al. An analysis of 2,480 space-occupying lesions of the orbit from 1976 to 2011. Ophthal Plast Reconstr Surg 2013; 29(2):79 86.
2. Shields JA, Shields CL. Orbital malignant melanoma: the 2002 Sean B Murphy lecture. Ophthal Plast Reconstr Surg 2003;19(4):262 9
3.Vlachostergios PJ, Voutsadakis IA, Papandreou CN. Orbital Metastasis of Breast Carcinoma. Breast Cancer Basic and Clin Res 2009 ;3: 91-97
4.E. S. P. Saad, H.M. Backi, A. Rayan, D. Barakat, and M.M. Khalel. Eye metastasis in breast cancer: case report and review of literature. ecancer 2022, 16:1353; www.ecancer.org; DOI: https://doi.org/10.3332/ecancer.2022.1353
5.Mouriaux F, Thariat J. Les métastases oculo-orbitaires. La lettre du cancérologue. Vol XXVI n°10, Novembre 2017
6.Razem B, Slimani F. An early orbital metastasis from breast cancer: A case report. Int J Surg Case Rep. 2021 Jan; 78:300-302. doi: 10.1016/j.ijscr.2020.12.049.
7.Milman T, Pliner L, Langer PD. Breast carcinoma metastatic to the orbit: an unusually late presentation. Ophthalmic Plast Reconstr Surg. 2008 Nov-Dec;24(6):480-2. doi: 10.1097/IOP.0b013e31818b6adc.
8. Surace D, Piscioli I, Morelli L, Valduga F, Licci S. Orbital metastasis as the first sign of "Dormant" breast cancer dissemination 25 years after mastectomy. Jpn J Ophthalmol. 2008 Sep-Oct;52(5):423-425. doi: 10.1007/s10384-008-0555-5.
9. Georgalas I, Paraskevopoulos T, Koutsandrea C, Kardara E, Malamos P, Ladas D, Papaconstantinou D. Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review. Biomed Res Int. 2015; 2015:574086. doi: 10.1155/2015/574086.
10. Tsutsui S, Kawata K, Ubagai T, Okimoto S, Fujihara M, Maeda T, Sonoda T. Orbital metastasis of invasive lobular carcinoma of the breast. J Surg Case Rep. 2022 Jan 21;2022(1): rjab619. doi: 10.1093/jscr/rjab619.
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